Acetyl Hexapeptide-8

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  Commonly referred to as ‘Botox in a jar’, it is a peptide compound used to reduce the appearance of fine lines caused by repeated facial expressions, such as crow’s feet, glabellar lines or nasolabial lines.

  Due to its similar structure to botulinum toxin, acetyl hexapeptide 8 in considered an excellent, non-invasive alternative to Botox (1). It promotes the skin’s natural production of type 1 collagen, the crucial protein which forms large, eosinophilic fibers to rebuild muscles, reducing fine lines and wrinkles. This ingredient blocks signals from the nerves to the muscles, these muscles can no longer retract, causing the wrinkles to relax and soften.

  It also optimizes collagen function, which, along with the skin-smoothing effects, improves moisture levels in the skin (2). 

  Research shows that it can reduce wrinkle depth by up to 30% when used for 30 consecutive days (3) (Figure 1).

 

 

 

 

 

 

 

Palmitoyl Tripeptide-1

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  Palmitoyl tripeptide-1, also called pal-GHK and palmitoyl oligopeptide (Sequence: Pal-Gly-His-Lys), is a messenger peptide for collagen renewal.

  Comparable to retinoic acid with regards to its activity, it does not trigger irritation. Collagen and glycosaminoglycan synthesis are stimulated, the epidermis is reinforced, and wrinkles are diminished (2) .

  It is used in cosmetic anti-wrinkle skincare and make-up products. In a study with 15 women, a cream containing palmitoyl tripeptide-1 was applied twice daily for four weeks, leading to statistically significant reductions in wrinkle length, depth and skin roughness (4).

 

 

 

Copper Tripeptide-1

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  Several copper(II)-peptide complexes occur naturally. In human plasma, the level of GHK-Cu is about 200 ng/ml at age 20. By the age of 60, the level drops to 80 ng/ml.

  In humans, GHK-Cu is proposed to promote wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth.

  Other studies revealed its ability to modulate expression of a large number of human genes, generally reversing gene expression to a healthier state. Synthetic GHK-Cu is used in cosmetics as a reparative and anti-aging ingredient (5,6) (Figure 2).

 

 

 

Synepin^TM Solution 100 (1%)

 

  Skin regeneration, Anti-aging, Scar care, Wound healing Agent

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　 Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6.2 kDa and has 53 amino acid residues and three intramolecular disulfide bonds. It is known to play key roles in skin regeneration and wound-healing.

 

　As an epidermal growth factor (EGF) tripeptide, Synepin^TM recognizes and binds to a specific site of EGF receptor that lies on cell membrane. Once this happens, EGF receptors deliver a signal to increase the production of cells in a specific area.

 

　  Synepin^TM boosts cellular turnover by facilitating the growth of keratinocytes and dermal fibroblasts. It works by attracting cells to a wound site to initiate repair process, which is an essential part of skin regeneration.

 

 

1.  Synepin^TM activates ERK and Akt signaling pathway and promotes skin cell proliferation through EGFR.

 　

EGF is known to promote the activation of ERK and Akt signaling pathway.

　The effect of Synepin^TM on phosphorylation of ERK1/2 and Akt1 was mediated by EGFR on HaCaT cells and SynepinTM also facilitates the proliferation of human keratinocytes and dermal fibroblasts1 (Fig. 1).

 

 

 

 

2. Synepin^TM helps reduce wrinkles on the skin and works by attracting cells to a wound site to initiate repair process, which is an essential part of skin regeneration (Fig. 2).

 

 

3. Synepin^TM is a peptide consisted of 3 amino acids with similar efficacy to EGF, but it has a significantly much smaller size (about 500 Da) compared to the 6,200 Da protein EGF. This allows for much better skin absorption, and it effectively functions at the dermal layer, providing real benefits and efficacy for the skin. Therefore, Synepin^TM is also called, “Skin permeable EGF peptide”.

 

 

 

 

 

 

 

 

 

 

 

1. Lim, S.H., et al. Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Sci Rep 2018: 8, 1596

2. Schagen S. K. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics 2017;4(2):16 (doi.org/10.3390/cosmetics4020016)

3. Blanes-Mira, C., et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int. J. Cosmet. Sci. 2002;24:303–310

4. Lintner, K.; Peschard, O. Biologically active peptides: From a laboratory bench curiosity to a functional skin care product. Int. J. Cosmet. Sci. 2000;(22), 207–218

5. Pickart L. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008;19(8):969-88

6. Peter Elsner, et al. Cosmeceuticals and active cosmetics. Drug versus Cosmetics. 2nd Edition. 2005. p.550-561

Apply morning and evening on face and neck. All skin types. Best use with Ciracle Anti-Wrinkle Drama Peptide Cream.